Immunohematological analysis process (ILV)

Course numberB3.06651.30.390
Course codeImmunhAP
Semester of degree program Semester 3
Mode of delivery Presencecourse
ECTS credits3,0
Language of instruction German

Based on an understanding of the physiological and pathophysiological regulatory mechanisms of hematopoiesis and the immune system and based on a doctor's order, students are able to independently carry out the biomedical analysis process (pre-analytical, analytical and post-analytical phases) in and immunohematology as part of the medical overall process. They i.e.:

  • Can assign the relevant measures to the bioanalytical and medical questions, can understand the reasoning for those measures and judge the quality of the material at hands
  • Know the preanalytical influencing and method-dependent disturbance variables for the respective measured quantities and their effects on the respective laboratory examination
  • Can select, critically assess and evaluate the immunohematological analysis methods according to the question
  • Know the basic reaction processes in the analysis process and recognize them in the automated processes
  • Based on their knowledge of the measuring process, evaluation, method-specific measured values, measurement results and calculation methods, they can relate to methods of data acquisition and relate them to the functionality of current and new device technologies
  • Apply selected hematological / immunohematological analysis (blood group serology and pre-transfusion examinations) to different sample materials using appropriate measurement, detection and assessment methods based on manuals
  • Are able to coordinate work processes and to schedule them efficiently
  • Can independently carry out and assess the subject-specific quality assurance measures
  • Can identify simple mistakes in the implementation of a method, allocate them correctly and remedy them as far as possible
  • Can document the study results with existing information technologies
  • Can properly handle the storage and transport of assay materials and reagents
  • Apply laboratory-specific hygiene measures as well as occupationally relevant legislation, guidelines and standards in immunohematology / transfusion medicine in an appropriate way
  • Are able to technically and biomedically validate results, to assess their significance for clinical diagnostics and to - taking the patient into account - connect the various immunohematological findings, place them in an overall picture and be aware of its consequences for the patient
  • Can, based on the available laboratory results, logically select further laboratory analysis (step-by-step diagnostics) and know about the mother-child passport diagnostics in the context of immunohematology
  • Know about the manufacture and use of blood products and they know about the need to track current developments and integrate them into their work

Modules of the 1st and 2nd semester

  • Immunohematologically relevant basics of the ABO system, rhesus system and other feature specific systems of the erythrocytes
  • Immunohematological analysis process (pre-analytics, analytics, post-analysis including quality assurance, documentation, technical and biomedical validation and interpretation of results, reporting, archiving of results)
  • Performing immunohematological examinations including pre-transfusion studies and mother-child pass examinations including laboratory exercises
  • Manufacturing process and use of blood products

Murphy K. M. & Weaver C. (2018), Immunologie, Spektrum;
Luttmann W. et al. (2014), Der Experimentator: Immunologie, Spektrum;
Schönitzer D. (1997), Prätransfusionelle Untersuchungen, Karger Verlag;
Eckstein R. & Zimmermann R. (2010), Immunhämatologie und klinische Transfusionsmedizin, Elsevier;
Mueller-Eckhardt C. & Kiefel V. (2010), Transfusionsmedizin, Springer;
Lanzer G. (2010), Kompendium der Transfusionsmedizin: Sichere Anwendung von Blutkomponenten, Springer;
Books, journals and websites according to the current state of knowledge in the respective fields.

Lectures, demonstrations, laboratory exercises, discussions