Basics of immunology (VO)

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Course numberB3.06651.10.160
Course codeImmGL
Curriculum2019
Semester of degree program Semester 1
Mode of delivery Presencecourse
SPPW2,0
ECTS credits2,0
Language of instruction German

The students know the structure and function of the components of the immune system and basic mechanisms of the development of immunocompetent cells as well as the foreign / self-differentiation. They understand the applications of immunological analysis methods based on immunological reactions.

  • Immunological basics: components of the immune system (structure and function of lymphoid organs, characterization and function of the cell system of the immune defense , biochemical structure and function of immune defense, initiation, organization and phases of immune defense, primary and secondary immune response, inflammation, immune mediators, immunological memory);
  • Mechanisms of innate immunity (e.g., phagocytosis, burst, acute phase response, inflammation, leukocyte migration)
  • Recognition mechanisms (MHCI, MHCII, cell receptors, antibodies and immune reaction, complement system)
  • Lymphocyte development (clonal selection, somatic recombination)
  • Mechanisms of immune tolerance
  • Immune response to specific pathogens
  • Basics of immunological analysis methods
  • Introduction: definitions, composition and structure of antibodies, antibody classes, antigens, antibody reactions, antibody acquisition, significant parameters of Ag / Ab reactions
  • Heidelberger Kendall curve; overview of immunochemical analysis methods: e.g. immunagglutination, immunoprecipitation, immunodiffusion and complement fixation; direct and indirect Ag / Ab detection using selected examples

Bröker B. et al. (2019), Grundwissen Immunologie, Spektrum
Murphy K. & Weaver C. (2018), Janeway Immunologie, Spektrum
Schmetzer O. (2015), Immunologie - Basics, Elsevier;
Rink L. et al. (2015), Immunologie für Einsteiger, Spektrum;
Pezzutto A. et al. (2006), Taschenatlas der Immunologie: Grundlagen, Labor, Klinik, Thieme;
Books, journals and websites according to the current state of knowledge in the respective fields.